Fig. 7: Long-range chromatin remodeling of a 6.1 Mb involving SOX11 in cMCL. | Nature Communications

Fig. 7: Long-range chromatin remodeling of a 6.1 Mb involving SOX11 in cMCL.

From: Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

Fig. 7: Long-range chromatin remodeling of a 6.1 Mb involving SOX11 in cMCL.The alternative text for this image may have been generated using AI.

a Heatmaps showing eigenvector coefficients of compartments significantly changing in cMCL vs. nnMCL (n = 673) and in uCLL vs. mCLL (n = 47). b Left: Genome-wide distribution of compartments (its position is determined with orange vertical lines) changing in MCL subtypes. Right: Relative abundance of the compartments significantly gaining activity in cMCL or nnMCL as compared with a random probability evaluated using a Monte-Carlo test (one-tailed). A gain in compartment activation was defined as an increase of the eigenvector coefficient of at least 0.4. *p value < 0.05, ****p value < 0.0001. c Heatmap showing eigenvector coefficients of compartments specifically gaining activation in cMCL (n = 93) in chromosome 2. On top of the heatmap, a 6.1 Mb genomic block gaining activation in 2p25 is highlighted. d Top: Differentially expressed genes between cMCL and nnMCL in each of the three cohorts of transcriptional data of MCL patients. Bottom: Compartment definition tracks on all the MCL cases. Eigenvalue subtraction between a representative cMCL and an nnMCL cases highlighting the 6.1 Mb region gaining activity in the former.

Back to article page