Fig. 2: Correlation of SNP effect estimates between the European POAG meta-analysis and the replication dataset. | Nature Communications

Fig. 2: Correlation of SNP effect estimates between the European POAG meta-analysis and the replication dataset.

From: Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Fig. 2: Correlation of SNP effect estimates between the European POAG meta-analysis and the replication dataset.The alternative text for this image may have been generated using AI.

The x-axis shows effect estimates in log(OR) scale for the independent genome-wide significant loci obtained from the meta-analysis of POAG in Europeans (16,677 POAG cases vs. 199,580 controls). The y-axis shows the effect estimates in log(OR) scale for the same SNPs obtained from meta-analysis of the following three GWAS data: glaucoma self-reports in UKBB, POAG in Asians, and POAG in Africans (the overall sample size of 17,502 cases and 149,741 controls). Red dots are the previously identified risk loci and blue dots are the previously unreported risk loci identified in this study. Horizontal gray bars on each dot represent the 95% confidence intervals (CIs; mean values + / − 1.96*SEM) for the effect estimates in Europeans (from the GWAS meta-analysis of 16,677 POAG cases vs. 199,580 controls), and vertical gray bars shows the 95% CIs in the replication dataset (from the GWAS meta-analysis of 17,502 POAG cases vs. 149,741 controls). The blue line is the linear regression line best fitting the data. The shaded area shows the 95% CIs on the repression line. UKBB UK Biobank, POAG primary open-angle glaucoma, OR odds ratio.

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