Fig. 5: Enrichment analyses highlight specific tissues and cell types in which the identified genes are highly expressed.

Human tissues (a) as well as rat micro-dissected kidney tubule cell types (b) were evaluated. Tissues are based on GTEx Project data V8, transcriptome data of kidney tubule cell types on the publication by Lee et al.⁴⁰ and proteome data of same cell types on the publication by Limbutara et al.³⁹. a Gene expression levels are from 39 non-brain tissues from GTEx V8. Presented values are the mean of log₁₀-transformed Transcript Per Million (TPM) of samples in each tissue. Only 29 genes are displayed because OR5R1 is not included in GTEx V8. b S1, first segment of proximal tubule; S2, second segment of proximal tubule; S3, third segment of proximal tubule; DTL1, descending thin limb type 1 (short-looped nephron); DTL2, descending thin limb type 2 (long-looped nephron); DTL3, descending thin limb type 3 (long-looped nephron); ATL, ascending thin limb; mTAL, medullary thick ascending limb; cTAL, cortical thick ascending limb; DCT, distal convoluted tubule; CNT, connecting tubule; CCD, cortical collecting duct; OMCD, outer medullary collecting duct; IMCD, inner medullary collecting duct. Presented values are the mean of log₁₀-transformed TPM of samples in each cell type. There was no rat homolog for SUGCT; NAT1 has two homologues (NAT1 and NAT2). ACSF3, ACY1, BBOX1, CALY, HAL, OR5R1, and RIOX1 were not included in the transcriptome dataset. Source data are provided as a Source Data file.