Table 2 Genes significantly associated with urine levels of ratios between fatty acids and amino acids.
Ratio of metabolites A / B | Gene | Burden | SKAT | No. of used SNPs | Total MAC | ||||
|---|---|---|---|---|---|---|---|---|---|
p-value | p-gain | Lower metabolite p-value | p-value | p-gain | Lower metabolite p-value | ||||
Trans-2-hexenoylglycine/hexanoylglycine | ACADM | 7.2E−33 | 1.4E+20 | 1.0E−12 B | 7.5E−42 | 1.3E+27 | 9.4E−15 B | 6 | 109 |
4-Methylhexanoylglutamine/hexanoylglutamine | ACY1 | 2.9E−13 | 3.0E+08 | 8.6E−05 B | 3.6E−13 | 3.8E+08 | 1.4E−04 B | 8 | 127 |
N-acetylglycine/glycine | ACY1 | 1.7E−25 | 1.4E+06 | 2.4E−19 A | 1.4E−28 | 2.3E+08 | 3.1E−20 A | 8 | 123 |
Cystathionine/1-carboxyethylisoleucine | CTH | 7.4E−24 | 4.6E+22 | 3.4E−01 A | 2.5E−24 | 3.2E+22 | 7.8E−02 A | 3 | 93 |
Betaine/dimethylglycine | DMGDH | 1.9E−46 | 1.2E+10 | 2.4E−36 B | 1.4E−48 | 3.2E+14 | 4.5E−34 B | 10 | 128 |
Tigloylglycine/isovalerylglycine | IVD | 2.2E−09 | 1.1E+05 | 2.3E−04 B | 4.3E−12 | 1.2E+07 | 5.1E−05 B | 3 | 18 |
Tyrosine/phenylalanine | PAH | 4.2E−27 | 1.3E+22 | 5.4E−05 B | 5.4E−18 | 8.8E+14 | 4.7E−03 B | 12 | 85 |
Lysine/threonine | SLC7A9 | 8.0E−12 | 2.7E+06 | 2.2E−05 A | 5.6E−10 | 2.3E+06 | 1.3E−03 A | 10 | 53 |
