Fig. 7: HyPrColoc’s sensitivity analysis. | Nature Communications

Fig. 7: HyPrColoc’s sensitivity analysis.

From: A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

Fig. 7

Heatmap visualizing changes in the clusters of colocalized traits identified by HyPrColoc when using different choices of the colocalization prior pc = {0.05, 0.02, 0.01, 0.005} and algorithm thresholds \(P_R^ \ast = P_A^ \ast = \{ 0.5,0.6,0.7\}\). Cells appear darker when trait pairs cluster more often. Data were generated under scenario (iii) and when: a the single causal variant assumption is satisfied; or b the single causal variant assumption is violated.

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