Table 3 New CHD loci sharing colocalized associations with related traits.

From: A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

Chr

Locus

Traits

Colocalized SNP (consequence)

Gene

Known CHD locus (SNP)

PPFC (PPE)

Expressed gene (eQTL)

Protein (pQTL)

6

FHL5

CHD, SBP

rs9486719 (Intron)

FHL5

–

0.844 (0.1542)

–

–

10

CYP26A1

CHD, TG

rs2068888 (Downstream)

CYP26A1

–

0.8454 (0.7669)

–

–

16

ANKRD11

CHD, WC

rs11643561 (Intron)

ANKRD11

–

0.7827 (0.0795)

–

–

19

RSPH6A

CHD, SBP

rs8108474 (Intron)

RSPH6A

–

0.7802 (0.1435)

–

–

20

PREX1

CHD, SBP, DBP

rs79044887 (Intron)

PREX1

–

0.7237 (0.132)

–

–

  1. HyPrColoc identified five regions—not yet reported as CHD genetic risk loci—with colocalized associations across CHD and one or more related trait. See Table 1 for a full description of table items.
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