Fig. 4: Comparison of methylation ITH by epiallele shifts in different genomic regulatory regions and PMDs.
From: Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
a Cumulative distribution curves of epiallele shifts (from IPN specimens versus its matched normal lung tissues) of consecutive loci located in promoters, enhancers, transcribed regions, and repressed regions (heterochromatin) are shown, with 1st percentile of entropy as −34.07 for all genomic regions, −30.87 for promoters, −38.12 for enhancers, −42.44 for transcribed regions, −45.48 for repressed regions, and −29.51 for repetitive regions by quantile regression. Cumulative distribution of epiallele shifts (from IPN specimens versus its matched normal lung tissues) of consecutive loci located inside PMDs (red) versus outside PMDs (blue), with 1st percentile of entropy as −29.10 inside PMDs and −20.73 outside PMDs in AAH (b), −37.60 inside PMDs and −28.05 outside PMDs in AIS (c), −44.74 inside PMDs and −29.25 outside PMDs in MIA (d), −50.82 inside PMDs and −41.25 outside PMDs in ADC (e) by quantile regression. The boundary of PMDs is derived from WGBS profiling of normal lung. Source data is provided as a source data file.
