Table 1 Anti-inflammatory marker inhibition and receptor activation parameters of eVDs and epoxy-eVDs.
NO production IC50 (μM) | IL-6 expression IC50 (μM) | TRPV1 % activationa | TRPV1 EC50 (IC50)b | CB1 % activationc | CB1 EC50b | CB2 % activationc | CB2 EC50b | |
|---|---|---|---|---|---|---|---|---|
NADA | 0.909 ± 0.076 | 0.507 ± 0.065 | 83.8 ± 13.6 | 962 ± 249 | 83.9 ± 9.2 | 0.045 ± 0.01 | --- | DNBd |
14’,15’-epoNADA | 0.888 ± 0.135 | 0.807 ± 0.440 | 79.7 ± 9.8 | 156 ± 36 | 92.3 ± 11.2 | 0.080 ± 0.03 | --- | DNBd |
NA5HT | 2.14 ± 0.06 | 1.06 ± 0.49 | --- | (7,650 ± 1,300) | --- | DNBd | 19.2 ± 3.4 | 8.80 ± 5.57 |
14’,15’-epoNA5HT | 2.07 ± 0.18 | 1.56 ± 0.22 | 23.6 ± 4.4 --- | 120 ± 27 (254 ± 38) | 99.9 ± 13.1 | 16.5 ± 11.7 | --- | DNBd |