Fig. 6: AgPd0.38 as a coating additive enabled an inert catheter to biocompatibly inhibit biofilm formation in mouse models.
From: Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action
a Schematic illustration on the preparation of Ca/PDA/AgPd, which was done by a coating of a catheter (abbreviated as “Ca”) (2.2/3.4 mm in inner/outer diameters) successively with dopamine and AgPd0.38. b Photographs of (from left to right) the pristine Ca, the intermediate Ca/PDA, and the final Ca/PDA/AgPd catheters. c Schedule of the test on the performance of Ca/PDA/AgPd inserted topically in P. aeruginosa PAO1-infected wounds in mouse models. Ca/PDA and PBS were included as controls. d Photograph of a Ca/PDA/AgPd inserted topically in a P. aeruginosa PAO1-infected wound in a mouse model. e (Top) Photograph and (bottom) confocal fluorescence microscopy image of a Ca/PDA/AgPd catheter collected carefully after 5-day insertion in a PAO1-infected wound therein and then cut open along its longitudinal axis, with those of Ca/PDA-treated similarly included for comparison. f Photographs of wounds treated with (from top to bottom) PBS, Ca/PDA, and Ca/PDA/AgPd throughout the observation window. g, h Serum levels of g white blood cell (WBC) and h neutrophil in mice from different treatment groups on differing days. Data points are reported as mean ± standard deviation (n = 4 for PBS or Ca/PDA treatment, n = 5 for others). * and ** indicate p < 0.05 and p < 0.01, respectively, analyzed by two-sided Student’s t-test. i Average CFU per wound for different treatment groups on day 8. Data points are reported as mean ± standard deviation. Source data are provided in the Source Data file.
