Table 1 Binding of Pangolin-CoV and SARS-CoV-2 S to ACE2s from different species.

From: Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

Spike

ACE2

Kd amplitude (nM)

Kd kinetics (nM)

SARS-CoV-2

Human

110 ± 14.7

75.5 ± 12.9

Pangolin

987 ± 112

896 ± 225

Pangolin-CoV

Human

74.0 ± 13.0

42.1 ± 10.0

Pangolin

850 ± 169

663 ± 139

  1. Equilibrium dissociation constants determined from the analysis of the data in Fig. 1 (Kd Amplitude) compared with values determined from analysis of the corresponding kinetic data (Kd Kinetics) (see Fig. S1).
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