Table 2 Variants associated with participation from genome-wide association analyses in the UK Biobank (P < 6 × 10⁻⁹).

FFQ

rs11210871

1

44,029,353

C/G

−0.59 (0.10)

1.80E-09

Yes (MHQ)

NA

Associated with intelligence—C-allele lower intelligence (PMIDs: 29326435, 29942086)

In LD with variants associated with ADHD (rs11210887, r² = 0.86, PMID: 30610198), smoking initiation (rs3001723, r² = 0.90, PMID: 30617275), risk tolerance (rs3001723, r² = 0.91, PMID: 30643258) and schizophrenia (rs3001723, r² = 0.91, PMID: 26198765)

FFQ

rs76473275

1

243,460,555

T/C

−0.88 (0.13)

3.10E-12

NA

FFQ

rs13428598

2

144,250,487

C/T

−0.65 (0.09)

1.20E-12

Yes (MHQ)

NA

Associated with cognitive function, intelligence and educational attainment (PMIDs: 29326435, 30038396)

In LD with variants associated with chronotype (rs28380327, r² = 0.94, PMID: 30696823) and neuroticism (rs10048736, r² = 0.94, PMID: 29942085)

FFQ

rs11134465

5

167,037,934

G/A

−0.60 (0.10)

4.40E-10

Yes (MHQ)

NA

FFQ

rs9261655

6

30,288,283

G/C

0.86 (0.15)

4.00E-09

NA

Associated with blood cell traits (PMID: 27863252)

FFQ

rs2622102

7

153,495,423

A/G

0.60 (0.09)

5.30E-11

Yes (MHQ)

NA

In LD with variants associated with alcohol consumption (rs6951574, r² = 0.91, PMID: 30643251), regular attendance at pub or social club (rs6969458, r² = 0.92, PMID: 29970889), smoking status (rs6951574, r² = 0.91, PMID: 30595370), risk-taking (rs2533148, r² = 0.86, PMID: 30643258)

FFQ

rs200373

19

18,286,546

T/A

0.52 (0.09)

4.80E-09

Yes (physical activity and MHQ)

NA

FFQ

rs147412694

21

40,702,786

G/A

−0.77 (0.13)

9.60E-10

NA

Associated with blood cell traits (PMID: 27863252)

In LD with variants associated with smoking status (rs77217252, r² = 0.85, PMID: 30595370)

Physical activity

rs55714539

19

18,207,397

A/C

1.08 (1.05, 1.11)

1.30E-09

Yes (FFQ and MHQ)

NA

Associated with multiple sclerosis (PMID: 24076602)

MHQ

rs7542974

1

72,544,704

G/A

0.97 (0.96, 0.98)

1.30E-09

Yes, lead SNP

Associated with cognitive function (PMID: 30038396) and intelligence (PMID: 29942086)

MHQ

rs485929

1

74,678,285

A/G

0.97 (0.96, 0.98)

4.00E-10

Yes, lead SNP

Associated with cognitive function (PMID: 30038396) and intelligence (PMID: 29942086)

MHQ

rs618232

1

84,357,225

A/C

1.03 (1.02, 1.04)

1.30E-09

Yes, within 500 kb of SNP rs532246 (r² = 0.9947)

MHQ

rs1565440

1

243,387,788

G/A

1.03 (1.02, 1.04)

6.50E-13

Yes (FFQ)

Yes, within 500 kb of SNP rs2789111 (r² = 0.8612)

Associated with risk-taking behaviour (PMID: 30271922)

In LD with a variant associated with educational attainment (rs3897821, r² = 0.86, PMID: 30038396)

MHQ

rs1012940

2

184,534,996

A/C

0.97 (0.96, 0.98)

9.70E-10

No

MHQ

rs34631

5

60,526,326

T/C

0.97 (0.96, 0.98)

1.20E-10

Yes, within 500 kb of rs34635 (r² = 0.6629)

In LD with variants associated with self-reported maths ability (rs194369, r² = 0.98, PMID: 30038396) and general cognitive ability (rs34627, r² = 1, PMID: 29844566)

MHQ

rs2844472

6

31,589,676

A/G

1.03 (1.02, 1.04)

1.60E-09

Yes (FFQ)

Yes, within 500 kb of rs3993747 (r² = 0.9636)

Associated with multiple sclerosis (PMID: 24076602, rheumatoid arthritis) (PMID: 23143596), blood traits (PMID: 27863252), psoriasis (PMID: 23143594) and SLE (PMID: 26502338)

In LD with a variant associated with height (rs2857693, r² = 0.89, PMID: 25282103)

MHQ

rs11793831

9

23,362,311

G/T

0.97 (0.96, 0.98)

8.60E-11

Yes, lead SNP

Associated with cognitive performance (PMID: 30038396), intelligence (PMID: 29942086), self-reported educational attainment (PMID: 27046643) and bipolar disorder (PMID: 27329760)

MHQ

rs2236295

10

64,564,892

G/T

1.03 (1.02, 1.04)

5.90E-09

No

Associated with urinary albumin—G allele higher albumin (PMID: 30220432)

In LD with a variant associated with diastolic blood pressure (rs10995311, r² = 0.81, PMID: 27618447)

MHQ

rs7910869

10

67,964,514

T/C

0.97 (0.96, 0.98)

7.60E-10

No

MHQ

rs1223114

11

31,523,130

A/G

1.03 (1.02, 1.04)

1.80E-09

Yes, within 500 kb of rs1984389 (r² = 0.6852)

MHQ

rs17145219

11

83,167,337

C/G

1.04 (1.03, 1.06)

2.90E-09

No

MHQ

rs7108020

11

131,289,820

C/A

0.97 (0.96, 0.98)

8.70E-12

Yes, within 500 kb of rs10791143 (r² = 0.8252)

Associated with educational attainment and highest math class taken—A associated with higher attainment (PMID: 30038396)

MHQ

rs35917376

15

75,595,357

T/A

1.03 (1.02, 1.04)

4.40E-09

Yes (FFQ)

No

MHQ

rs8055041

16

7,462,715

C/G

0.97 (0.97, 0.98)

1.40E-09

Yes, within 500 kb of rs4616299 (r² = 0.7553)

MHQ

rs7207531

17

56,426,789

G/A

0.97 (0.96, 0.98)

1.30E-09

Yes, within 500 kb of rs56058331 (r² = 1)

MHQ

rs1261078

18

52,866,791

A/G

1.07 (1.05, 1.09)

5.50E-12

Yes, lead SNP

MHQ

rs35502362

19

4,966,041

C/T

0.97 (0.96, 0.98)

3.20E-09

Yes, within 500 kb of rs34232444 (r² = 1)

Associated with haematological traits (PMID: 27863252)

MHQ

rs3746187

19

18,279,816

A/G

1.03 (1.02, 1.04)

1.80E-10

Yes (FFQ and actigraphy)

Yes, lead SNP

In LD with a variant associated with the number of sexual partners (rs273512, r² = 0.84, PMID: 30643258)

MHQ

rs429358

19

45,411,941

T/C

1.06 (1.05, 1.07)

1.10E-20

Yes, lead SNP

Highly pleiotropic APOE variant— associated with Alzheimer’s disease, cholesterol, CRP etc.

MHQ

rs1232482

20

11,886,643

C/T

0.97 (0.96, 0.98)

2.30E-09

No

In LD with variants associated with diastolic blood pressure (rs1232482, r² = 1, PMID: 30224653, cigarettes per day (rs6078373, r² = 0.93, PMID: 30643251)

Aide-memoire

rs2049604

7

113,990,352

C/T

0.97 (0.96, 0.98)

4.60E-09

NA

Aide-memoire

rs58101275

14

104,008,420

G/A

0.96 (0.95, 0.98)

5.00E-09

NA

Associated with heel bone mineral density (PMID: 30598549) and isoleucine levels (PMID: 27898682)