Fig. 4: Identification of gene fusion events by both RNA-seq and SSVs.

a Out of 19,211 candidate fusion events identified by RNA-seq analysis (using Arriba or STAR-fusion algorithms), numbers of events with support from SSV analyses. As indicated, for 1866 candidate fusion events, SSV breakpoints were found within one or both genes, with or without a high expression association (see Methods). b Of the 415 gene body SSV breakpoint events associated with overexpressed genes (70 genes with FDR < 10% correcting for tumor type and CNA), the fractions of events associated with either gene fusion by combined RNA-seq and SSV analysis or high-level gene amplification are indicated. c Gene fusions with both RNA-seq and SSV support with high expression association, and involving either greater than two tumors (KCNS3-MYCNOS, TARSL2-WFS1) or greater than one tumor plus a COSMIC gene²⁰ are represented. Tumor type is indicated along the bottom and in the coloring of the fusion event.