Table 2 Cut-off values, and estimated sensitivity and specificity of RMOD resulting from ROC analysis performed using different reference methods (LM, PCR, RDT) and different infection characteristics.
From: Magneto-optical diagnosis of symptomatic malaria in Papua New Guinea
Cut-off (mV/V)a | Sensitivity (%)a | Specificity (%)a | κa,b | |
|---|---|---|---|---|
LM result | ||||
all LM positive | 4.19 | 82 (78–86) | 84 (81–86) | 0.64 |
P. falciparum | 4.00 | 79 (73–84) | 83 (80–86) | 0.57 |
P. vivax | 5.15 | 87 (80–92) | 88 (85–90) | 0.63 |
P.f + P.v. (mixed) | 10.20 | 95 (76–100) | 96 (94–97) | 0.55 |
PCR result | ||||
all PCR positive | 3.54 | 78 (73–82) | 78 (75–81) | 0.54 |
P. falciparum | 3.01 | 80 (74–85) | 75 (71–78) | 0.47 |
P. vivax | 4.84 | 79 (71–86) | 84 (81–87) | 0.51 |
P.f.+P.v. (mixed) | 5.40 | 80 (61–91) | 85 (82–88) | 0.24 |
RDT result | ||||
all RDT positive | 4.11 | 76 (71–80) | 83 (79–86) | 0.58 |
PfHRP2 | 2.58 | 65 (52–77) | 70 (66–73) | 0.16 |
pLDH | 5.14 | 81 (71–88) | 87 (84–90) | 0.55 |
PfHRP2+pLDH | 4.11 | 81 (75–86) | 83 (79–86) | 0.57 |
