Fig. 1: Two different fibril protein conformations underlie the FOR005 amyloid fibrils.
From: Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis
a Side views of the 3D maps of fibril structures A and B (left, gray), and corresponding molecular models (right, green/magenta). b Side view of longer segments of the two molecular models. c, d Cross-sectional views of the fibril protein conformations A (c) (EMD-11031) and B (d) (EMD-11030). Blue asterisk: region with blurry density surrounding the fibril core. Red asterisk: extra density decorating the fibril core, indicating an ordered peptide conformation. e Overlay of the molecular models of fibril structures A (PDB: 6Z10) and B (PDB: 6Z1I). The N- and C-terminal residues of the model are highlighted.
