Fig. 6: The origin of structural breaks: two possible scenarios.
From: Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis
Schematic representation of a stack of fibril proteins, illustrating two different hypotheses on how structural breaks form: during fibril extension (left) or after fibril formation (right). Conformation A is represented by two β-sheets (green). Conformation B is represented by one β-sheet (magenta). Disordered segments are represented by dotted gray lines. Gray arrows represent the immature fibril proteins, before the mature conformations A and B are fully adopted.
