Table 1 Node and edge overlap between individualized patient HCM networks.

Node overlap between individual-patient HCM networks
	HCM 1	HCM 2	HCM 3	HCM 4	HCM 5	HCM 6	HCM 7	HCM 8	HCM 9	HCM 10	HCM 11	HCM 12	HCM 13	HCM 14	HCM 15	HCM 16	HCM 17	HCM 18
HCM 1	1	0.75	0.60	0.72	0.73	0.73	0.78	0.76	0.72	0.70	0.64	0.72	0.79	0.70	0.80	0.74	0.77	0.72
HCM 2		1	0.64	0.71	0.74	0.76	0.71	0.75	0.78	0.73	0.67	0.68	0.78	0.68	0.76	0.69	0.70	0.69
HCM 3			1	0.59	0.63	0.63	0.64	0.75	0.61	0.61	0.64	0.59	0.76	0.67	0.71	0.64	0.64	0.67
HCM 4				1	0.64	0.63	0.80	0.77	0.63	0.65	0.60	0.83	0.76	0.70	0.85	0.81	0.79	0.66
HCM 5					1	0.66	0.76	0.78	0.69	0.73	0.68	0.72	0.83	0.77	0.79	0.77	0.78	0.75
HCM 6						1	0.79	0.77	0.66	0.69	0.66	0.74	0.82	0.74	0.79	0.76	0.79	0.72
HCM 7							1	0.74	0.75	0.72	0.64	0.79	0.80	0.71	0.81	0.78	0.79	0.70
HCM 8								1	0.76	0.75	0.79	0.74	0.71	0.75	0.70	0.73	0.74	0.74
HCM 9									1	0.75	0.65	0.69	0.82	0.71	0.77	0.73	0.74	0.73
HCM 10										1	0.65	0.65	0.83	0.72	0.76	0.71	0.71	0.74
HCM 11											1	0.58	0.78	0.69	0.74	0.64	0.65	0.71
HCM 12												1	0.78	0.71	0.85	0.81	0.82	0.67
HCM 13													1	0.83	0.72	0.79	0.78	0.81
HCM 14														1	0.75	0.71	0.71	0.71
HCM 15															1	0.80	0.82	0.73
HCM 16																1	0.75	0.66
HCM 17																	1	0.67
HCM 18																		1

Edge overlap between individual-patient HCM networks
	HCM 1	HCM 2	HCM 3	HCM 4	HCM 5	HCM 6	HCM 7	HCM 8	HCM 9	HCM 10	HCM 11	HCM 12	HCM 13	HCM 14	HCM 15	HCM 16	HCM 17	HCM 18
HCM 1	1	0.56	0.32	0.54	0.56	0.57	0.59	0.44	0.53	0.50	0.37	0.51	0.50	0.42	0.51	0.52	0.56	0.48
HCM 2		1	0.32	0.47	0.53	0.59	0.49	0.40	0.60	0.56	0.39	0.46	0.49	0.39	0.46	0.41	0.45	0.42
HCM 3			1	0.30	0.36	0.36	0.32	0.40	0.33	0.32	0.35	0.26	0.39	0.31	0.32	0.29	0.30	0.36
HCM 4				1	0.45	0.44	0.65	0.46	0.42	0.39	0.30	0.73	0.45	0.41	0.66	0.66	0.61	0.38
HCM 5					1	0.47	0.57	0.48	0.51	0.52	0.43	0.52	0.58	0.54	0.52	0.56	0.59	0.52
HCM 6						1	0.62	0.47	0.48	0.49	0.42	0.56	0.56	0.51	0.54	0.56	0.61	0.50
HCM 7							1	0.42	0.55	0.51	0.33	0.67	0.55	0.46	0.57	0.61	0.65	0.46
HCM 8								1	0.43	0.43	0.51	0.44	0.37	0.42	0.33	0.41	0.41	0.43
HCM 9									1	0.56	0.38	0.46	0.55	0.41	0.47	0.48	0.52	0.48
HCM 10										1	0.40	0.41	0.58	0.44	0.45	0.45	0.47	0.51
HCM 11											1	0.29	0.48	0.38	0.37	0.31	0.32	0.44
HCM 12												1	0.53	0.47	0.68	0.67	0.69	0.42
HCM 13													1	0.66	0.37	0.54	0.52	0.58
HCM 14														1	0.45	0.48	0.47	0.48
HCM 15															1	0.57	0.61	0.40
HCM 16																1	0.57	0.40
HCM 17																	1	0.40
HCM 18																		1

The transcriptomic profile of anterior septal myectomy specimens from patients with hypertrophic cardiomyopathy (HCM) (N = 18) was analyzed using a two-step method that included a correlation matrix and protein–protein interaction analysis resulting in individualized patient networks. Nodes (representing proteins in the networks) common to individualized patient network pairs are presented in the top panel, and edges (representing interactions between proteins in the networks) common to individualized patient network pairs are presented in the bottom panel. 1, full overlap; 0, no overlap.

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