Fig. 5: Substrate shuttling within the catalytic chamber by the ACP domain.

a The LovBC complex is shown as surface representation. The hypothetical substrate shuttling trajectories (one side) within the catalytic chamber are shown as lines with each arrow pointing towards the next step; the active site residues locations of each domain (depicted in Supplementary Fig. 13) are marked as gray balls. The dashed arrow indicates the loading of the malonyl precursor. b Schematic diagrams depicting the iterative, yet permutative function of LovB. After each condensation, the substrate undergoes different tailoring processes. The solid lines indicate the steps in which the intermediates are processed by the domain. The bypassed steps in each cycle are depicted in dashed lines.