Fig. 5: The paratopes of Fab224, 399, and 366. | Nature Communications

Fig. 5: The paratopes of Fab224, 399, and 366.

From: Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

Fig. 5

a Crystal structure of Fab224 encoded by the IGHV3-49 gene and its epitope are shown as cartoons with residues where the main chain and side chain engage in hydrogen bonds (orange dashes) shown as sticks. The Fab cartoon representation is embedded in a transparent white surface rendering. Only the CDRs involved in the binding groove are displayed and colored green, blue, magenta, light green, and pink for CDR H1, H2, H3, L1, and L3, respectively. A schematic of the epitope is also illustrated below. b The binding groove of Fab399 encoded by the IGHV3-49 gene. c The paratope of Fab366 encoded by the IGHV1-2 gene. All representations and coloring schemes for (b) and (c) are as in (a). In addition, a surface representation of Fab366 is shown, where the black and white surfaces represent the heavy and light chains, respectively.

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