Fig. 2: Protein profiles in pancreatic tissue and alterations across multiple developmental stages.
From: Proteome-wide and matrisome-specific alterations during human pancreas development and maturation
a Hierarchical clustering of DiLeu reporter ion intensities of 2064 quantified proteins. b Hierarchical clustering of DiLeu reporter ion intensities of 1570 significantly changed proteins (one-way ANOVA, FDR 0.05). Six clusters of these proteins are depicted based on different intensity profiles across four developmental stages. Color of each line in clusters is based on its distance from the center, red (close) to blue (far). The number of proteins and selected enriched biological processes and pathways are indicated for each cluster. c Volcano plots showing pairwise comparisons of protein expression levels between various stages. Points above horizontal dashed lines represent significantly altered proteins (two-sided t test, p value < 0.05, p values were adjusted by Benjamini–Hochberg correction for multiple comparisons). Significantly downregulated proteins (e.g., lower abundance in J in the first plot) are shown in green (protein fold change < 0.5) and upregulated ones are shown in red (protein fold change > 2). F fetal, J juvenile, Y young adult, O older adult. Source data are provided as a Source Data file.
