Fig. 3: ECM remodeling during fetal and postnatal stages of human pancreas development.
From: Proteome-wide and matrisome-specific alterations during human pancreas development and maturation
a Hierarchical clustering of DiLeu reporter ion intensities of 117 quantified ECM proteins. b Volcano plots showing pairwise comparisons of ECM protein expression levels between various stages. Points above horizontal dashed lines represent significantly altered proteins (two-sided t test, p value < 0.05, p values were adjusted by Benjamini–Hochberg correction for multiple comparisons). Significantly downregulated proteins are shown in green (protein fold change < 0.5) and upregulated ones are shown in red (protein fold change > 2). Core matrisome proteins are annotated in each figure. c Box plots showing expression levels of selected proteins at different developmental stages. Red dots indicate replicate data points (F, Y, O: N = 6 donors per group; J: N = 5 donors). All box plots indicate median (center line), 25th and 75th percentiles (bounds of box), and minimum and maximum (whiskers). Significance level is marked with an asterisk (two-sided t test, p values were adjusted by Benjamini–Hochberg correction for multiple comparisons, *p value < 0.05, **p value < 0.01; n.s., not significant). F fetal, J juvenile, Y young adult, O older adult. Source data are provided as a Source Data file; exact p values are provided in the Source Data file.
