Table 2 Association of PHS with aggressive prostate cancer.

From: Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

OncoArray genetic ancestry

z (p Value)

Hazard ratios [95% CI] comparing percentiles of PHS2

HR20/50: ≤20th vs. 30–70th

HR80/50: ≥80th vs. 30–70th

HR98/50: ≥98th vs. 30–70th

HR80/20: ≥80th vs. ≤20th

All (n = 58,600)

47.6 (p < 10−300)

0.43 [0.41–0.44]

2.50 [2.42–2.60]

4.61 [4.33–4.90]

5.88 [5.48–6.34]

European (n = 53,608)

46.4 (p < 10−300)

0.44 [0.42–0.45]

2.45 [2.36–2.55]

4.40 [4.15–4.70]

5.62 [5.25–6.05]

Asian (n = 1806)

43.8 (p < 10−300)

0.45 [0.37–0.55]

2.32 [1.88–2.89]

4.14 [2.92–6.03]

5.16 [3.45–7.78]

African (n = 3186)

23.6 (p = 7.2 × 10−123)

0.64 [0.49–0.81]

1.55 [1.23–2.00]

2.18 [1.44–3.43]

2.43 [1.51–4.05]

  1. Hazard ratios (HRs) derived from Cox proportional hazards models are shown comparing men in the highest 2% of genetic risk (≥98th percentile of PHS), highest 20% of genetic risk (≥80th percentile), average risk (30–70th percentile), and lowest 20% of genetic risk (≤20th percentile) across genetic ancestry. p Values reported are two-tailed from the Cox models.
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