Table 3 Association of PHS with death from prostate cancer.

From: Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

Ancestry

z (p Value)

Hazard ratios [95% CI] comparing percentiles of PHS2

HR20/50: ≤20th vs. 30–70th

HR80/50: ≥80th vs. 30-70th

HR98/50: ≥98th vs. 30–70th

HR80/20: ≥80th vs. ≤20th

All (n = 78,221)

15.9 (p = 6.3 × 10−57)

0.43 [0.41–0.56]

2.47 [2.33–2.64]

4.46 [4.04–4.98]

5.68 [5.07–6.46]

  1. Hazard ratios (HRs) from Cox proportional hazards models are shown comparing men in the highest 2% of genetic risk (≥98th percentile of PHS), highest 20% of genetic risk (≥80th percentile), average risk (30–70th percentile), and lowest 20% of genetic risk (≤20th percentile). p Values reported are two-tailed from the Cox models.
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