Fig. 3: A discrete titer cut-off tracks with functional SARS-CoV-2 humoral and T cell immunity.
From: Discrete SARS-CoV-2 antibody titers track with functional humoral stability
A The dot plot shows the distribution of study maximum observed antibody titers (highest titer per individual observed in this study) across the cohort, split based on median titers. Dark blue shading indicates all individuals above the median and the light blue shows all the individuals below the median (ntotal = 120; nlow = 60, nhigh = 60). B The violin plots show the distribution of neutralizing antibody titers (dilution factor, left), antibody-dependent complement deposition (ADCD, mean fluorescence intensity, middle), and antibody-dependent neutrophil phagocytosis (ADNP, phagocytosis score, right)(nlow = 60, nhigh = 60) against SARS-CoV-2 S. C The violin plots show the neutralization levels, ADCD, and ADNP (n = 15) from the maximum observed titers to the next timepoint (P + 1) in a subset of individuals in the high titer group. D The correlation heat maps (Spearman-correlation) show significant correlations (p < 0.05) between RBD, Spike (S), and Nucleocapsid (N) titers in the high titer (right; n = 15) and low titer (left; n = 26) groups. Statistical differences between two groups were assessed with a two-sided non-parametric Mann–Whitney test in (B) and paired Wilcoxon-test in (C). ****p < 0.0001 or exact p-values for not significant comparisons. Source data are provided as a Source Data file.
