Fig. 4: A discrete titer cut-off tracks with functional SARS-CoV-2 humoral and T cell immunity.
From: Discrete SARS-CoV-2 antibody titers track with functional humoral stability
A, B The flower plots summarize titer and functional data against SARS-CoV-2 RBD, S or N antigen in high or low titer group at maximum observed titers (A) and the following timepoint (B) (the petal color corresponds to features as indicated; the univariate data are also shown in Fig. 3 and Supplementary Fig. 2). C–E Antibody-dependent virus neutralization (C), ADCD (D) or ADNP (E) by ELISA RBD titer. The black dotted line indicates the median split (0.45 μg/ml) and the red dashed line the threshold titer for the individual functions. F, G The violin plots show the number of spots forming cells (SFC) of interferon-gamma (IFNγ) secreting T cells after overnight stimulation with either an overlapping peptide pool covering SARS-CoV-2 S (F) or N (G) in individuals with low titers (light blue, n = 10), high titers (dark blue, n = 12) or negative controls (white, n = 14). Statistical differences between two groups were assessed with a two-sided non-parametric Mann–Whitney test (in (F) *:p = 0.039, in (G) *:p = 0.018). Source data are provided as a Source Data file.
