Fig. 5: Immunoglobulin G (IgG) antibody titer.

Enzyme-Linked Immunosorbent Assays (ELISA) were completed at each time point as shown. In four patients who had detectable anti- α-galactosidase A (α-gal A) antibodies, levels declined in three patients and rose in one patient, although the titers never reached the levels of a positive control sample collected following enzyme therapy (ET). Red arrow is at Day −30 when ET was stopped prior to mobilization. Green arrow is at Day 30 when ET was restarted for Patients 1, 2, 4, and 5. The orange arrow demarks when Patient 4 stopped ET at Day 214 and the blue arrow is when Patient 1 stopped ET at Day 548. Patient 3 chose not to restart ET.