Fig. 1: Information content of TF-chromatin interactions.
From: Chromatin information content landscapes inform transcription factor and DNA interactions
a Upper: TF binding impacts the chromatin architecture and the observed ATAC-seq fragment distribution around TF binding sites. Middle and bottom: calculation of CIE and f-VICE. b, c V-plots and CIEs of CTCF, AP-1, and NFKB (GM12878 ATAC-seq data generated in this study). V-plots were downsampled to highlight differences in chromatin architecture (but not for f-VICE calculation). d f-VICEs calculated for TFs with GM12878 ChIP-seq data. e F1 score sum of TF binding prediction algorithms. f Normalized GM12878 BMO-informed f-VICE distribution.
