Fig. 2: Large genomic structures are altered by early B-cell activation and mitosis.
From: Pre-mitotic genome re-organisation bookends the B cell differentiation process
a A/B compartmental interaction plots of in situ HiC data of the entirety of chromosome 12 at different B-cell activation stages. 100 kB resolution. b Proportion of TAD boundaries strengthening (red) or weakening (blue) at each transition of B-cell activation determined by diffHic. c 1–99th percentile boxplot of distributions of TAD size (bp) from replicate libraries called with TADbit at each stage of B-cell activation. A one-way ANOVA was used to determine significance. d, e Number of TADs detected that are larger (d) or smaller (e) than 800 kbp at each stage of B-cell activation in two biologically independent libraries. One-way ANOVAs were used to determine significance. f Distribution of DI spans (distance between anchors of significance DIs) for strengthened and weakened interactions at each B-cell differentiation transitions during B-cell differentiation (50 kbp resolution). Blue indicates DIs that are weakened (intensity fold-change < 1). Red indicates DIs that are strengthened (fold-change > 1). Source data are provided as a Source Data file.
