Fig. 1: Sialylation is increased in pancreatic ductal adenocarcinoma (PDAC). | Nature Communications

Fig. 1: Sialylation is increased in pancreatic ductal adenocarcinoma (PDAC).

From: Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

Fig. 1

A Representation of the different pathways that contribute to sialylation of glycans. B Gene set enrichment analysis of the pathways described in (A) in normal and tumour tissue. ΔGSVA score was calculated as the difference between the GSVA score in tumour and in normal tissue. C Immunohistochemistry analysis of the expression of sialylated glycans in normal and tumour tissue, using plant lectins specific for α2,3 (MAL I and MAL II) and α2,6 sialic acid (SNA). Data presented as mean values ± SEM. D–E Evaluation of sialic acid expression in PDAC cell lines by (D) ELISA and (E) flow cytometry. ΔD.O. at 450 nm was calculated as the difference of the O.D at 450 nm of the sample and the one of the uncoated control.

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