Fig. 8: Proposed model for m6A modification in promoting TFH differentiation.
From: METTL3-dependent m6A modification programs T follicular helper cell differentiation
During acute infection, METTL3-sufficient CD4+ T cells were activated. With m6A machinery, Tcf7 mRNA was m6A modified and stabilized, allowing normal production of TCF-1 protein. TCF-1 in turn regulates expressions of TFH cell regulators, which ultimately program TFH commitment, proliferation, survival, and functional maturation.
