Fig. 5: QKI deletion delays a subset of astrocyte transcript maturation. | Nature Communications

Fig. 5: QKI deletion delays a subset of astrocyte transcript maturation.

From: Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain

Fig. 5: QKI deletion delays a subset of astrocyte transcript maturation.

A Gene Ontology analysis of biological processes enriched by QKI loss reveal increased mitochondrial and cell proliferation. B CSEA of transcripts increased when QKI is deleted are disproportionately found in oligodendroglial progenitor cells. Cell-type-specific data is FPKM from ref. 21 (brainrnaseq.org). C CSEA of transcripts decreased when QKI is deleted are disproportionately found in adult astrocytes. Cell-type-specific data is FPKM from ref. 21 (brainrnaseq.org). D Transcripts increased when QKI deleted contain proportionally more P7 astrocyte transcripts. E Transcripts decreased when QKI deleted contain proportionally more P32 astrocyte transcripts. F Heatmap of transcripts both modulated by QKI mutation and differentially expressed between P7 and P32. G The 70 transcripts from D are highly enriched in cell cycle-related biological processes. The 30 transcripts from E did not significantly map to a defined biological process.

Back to article page