Fig. 1: Comparison of the ALT-probability score of Sieverling et al.2, with the new classifier proposed in this article.
From: Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX
The 2497 patients described in Sieverling et al. are divided here into two groups: ALT-high probability (upper bar) and ALT-low probability (lower bar) according to the new classifier. Within the two bars, each patient is represented by a symbol placed on a scale from 0 to 1 according to its Sieverling ALT-probability score. Star and inverted triangle symbols represent patients whose tumors were C-circle assay (CCA) positive or negative, respectively3, and the dots represent patients for whom CCA data are unavailable. Red and blue symbols correspond to patients with ATRX/DAXXtrunc and TERTmod alterations, respectively2. The pink and blue shading highlights the tumors for which the two scores were discordant: the pink shading in the upper box indicates tumors with ALT-high probability (new classifier), that were ALT-probability <0.75 (ALT-low) by Sieverling’s score; the blue shading in the lower box indicates tumors with ALT-low probability (new classifier), that were ALT-probability >0.75 (ALT-high) by Sieverling’s score.
