Fig. 4: Independent validation of the functional modules in bulk RNA sequencing and single-cell RNA sequencing cohorts. | Nature Communications

Fig. 4: Independent validation of the functional modules in bulk RNA sequencing and single-cell RNA sequencing cohorts.

From: Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma

Fig. 4

a The Pearson correlation analysis of functional scores (cytotoxic, exhaustion, naïve, and Treg) and the abundance of T cell subpopulations (NKG7+ cytotoxic T cells, exhausted T cells, naïve T cells, and Tregs) in the discovery cohort and validation cohort. b The Pearson’s correlation analysis of functional scores (cytotoxic, exhaustion, naïve, and Treg) and the abundance of T cell subpopulations (NKG7+ cytotoxic T cells, exhausted T cells, naïve T cells, and Tregs) in PY Chen, et al. NPC single-cell cohort. c The Pearson correlation analysis of functional scores and the corresponding genes in two GEO cohorts (GSE102349 and GSE68799), respectively. The two-sided p value for each functional module in GSE102349 and GSE68799 was extremely small (<1 × 10−15), therefore the exact p values cannot be shown in the figure. Source data are provided as a Source Data file.

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