Fig. 6: Comparison between HDX protected regions and crystal structures.

Combination of HDX-MS data with crystal structures of PvRBP2b human Fab fragments bound to PvRBP2b. Fabs are shown in transparent surface representation. Regions that show protection by HDX-MS for each mAb are colored and the residue range is labeled. Black indicates the regions where no peptides were detected by HDX-MS.