Fig. 3: BNM-III-170-bound and M48U1-bound Env inter-protomer dimensions match those of open CD4-bound Env. | Nature Communications

Fig. 3: BNM-III-170-bound and M48U1-bound Env inter-protomer dimensions match those of open CD4-bound Env.

From: Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation

Fig. 3: BNM-III-170-bound and M48U1-bound Env inter-protomer dimensions match those of open CD4-bound Env.

Structure colors: Protomer 1 = gray, protomer 2 = purple, protomer 3 = teal, BNM-III-170 = magenta, M48U1 = red. Top-down view of surface and cartoon rendering of a, BNM-III-170-bound and b, M48U1-bound Env trimer structures showing inter-protomer distance measurements between reference residues for the base of the V3 loop (His330gp120, blue), the base of the V1/V2 loop (Pro124gp120, green), and the CD4 binding site (CD4bs, Asp368gp120, yellow). 17b Fabs have been removed for clarity.

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