Table 1 Interprotomer distances of envelope trimers.

From: Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation

Average distances (Å)*

Structure

PBD code

State

V3 Base (His330gp120)

V1/V2 Base (Pro124gp120)

CD4bs (Asp368gp120)

BG505-IOMA-10-1074

5T3Z

Closed

69

14

54

BMS-626529-BG505-PGT122-35O22

5U70

Closed

69

14

55

b12-B41

5VN8

Open

75 ± 0.3 (n = 3)

69 ± 0.2 (n = 3)

85 ± 0.0 (n = 3)

sCD4-Env-17b

5VN3, 6U0L, 6U0N

Open

74 ± 4.0 (n = 9)

77 ± 5.9 (n = 9)

80 ± 5.0 (n = 9)

BNM-III-170-BG505-17b

This study

Open

76 ± 4.6 (n = 3)

74 ± 3.5 (n = 3)

84 ± 3.4 (n = 3)

M48U1-BG505-17b

This study

Open

77 ± 5.9 (n = 3)

75 ± 2.8 (n = 3)

86 ± 4.2 (n = 3)

  1. *For asymmetrically open structures, distances shown are mean ± s.d. of n number of protomers.
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