Fig. 3: Structure and mechanistic analysis of Rh(I)-catalyzed O6-G labeling.
From: Programmable site-selective labeling of oligonucleotides based on carbene catalysis
a Expanded 1H-13C HMBC (DMSO-d6) spectrum of 6. b Calculated nucleophilicity index of four canonical nucleobases (A, T, G, and C); transition state geometry of the catalyst approaching guanosine obtained by DFT calculations. c Reaction performed with N7-methyl-2′-deoxyguanosine and its HPLC trace.
