Fig. 4: Structure analysis of Rh(I)-catalyzed O6-G labeling of oligonucleotides.
From: Programmable site-selective labeling of oligonucleotides based on carbene catalysis
a HPLC analysis of the acetonylation of 7a. b Identification of G modification by MALDI-TOF/TOF analysis of 8a. Mass spectrum (MS) of 8a and its MS/MS fragmentation with labeled fragments. c Endonuclease digestion of acetonylated hairpin oligonucleotide 8b and the corresponding HPLC spectra for the analysis of the modification site. d MS of 8b and 9.
