Fig. 2: cAMP-dependent pathway alterations converge on GLI2 activity.

a Oncoprint summaries of all fusion, mutation, and copy number data (n = 196). Subtypes are denoted above. NA, not available. b Gene-level summary of GNAS events. c Mutual exclusivity of GNAS and PRKAR1A LOF events. LOF events include mutations and homozygous deletions. d Gene-level summary of PRKAR1A events. e cAMP dependant signaling pathway schematic. Red indicates activating alterations while blue indicates inactivating alterations. f, g Gene-level summary of (f) GLI2 events and (g) their overlaps. Mutations in f are shown as lollipop diagrams above the gene schematic and fusion events are shown below. The 5 prime and 3 prime orientation of the fusion transcript is indicated by the color orientation. In cases where GLI2 is the 3 prime partners, the fusion lollipop is red on the right.