Fig. 4: APOBEC3A can deaminate VpC sites in bacteria. | Nature Communications

Fig. 4: APOBEC3A can deaminate VpC sites in bacteria.

From: An extended APOBEC3A mutation signature in cancer

Fig. 4

A Relative APOBEC3A activity, measured as Uracilation Index (UI), at cytosines in VpC sequences in predicted hairpin loops in the genome of E. coli. Increased activity is observed at cytosines in NVC triloops (asterisks), but only on the lagging-strand template (LGST). B Comparison of relative APOBEC3A activity in VpC sequences. Increased activity is seen at VpC sites in the loops of strongly paired hairpins (asterisks). Activity at hairpin VpC sites is several times stronger than at non-hairpin TpC sites. Activity at hairpin TpC sites is much higher than comparable VpC sites. Source data are provided as a Source Data file.

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