Fig. 2: Species longevity is predicted by the mean rate of DNAm change.
From: DNA methylation predicts age and provides insight into exceptional longevity of bats
a After controlling for phylogeny using phylogenetic generalized least squares regression, mean DNAm rate at 1165 hypermethylating age DMPs correlate with longevity (r = −0.704, t = −4.95, P = 6.79e−5), b as does mean DNAm rate at 835 hypomethylating age DMPs (r = −0.682, t = −4.27, P = 3.42e−4). Species longevity is represented by the longevity quotient (LQ), which is the ratio of the observed species maximum lifespan to the maximum lifespan predicted for a nonflying placental mammal of the same body mass29. For example, the maximum longevity of Myotis lucifugus (10) is over six times longer than expected, while the maximum longevity of Molossus molossus (9) is equal to an average placental mammal of the same body size. The five species used for identifying longevity DMPs by the difference in methylation rate are indicated by red triangles (long-lived) and blue triangles (short-lived). Only species with more than ten samples are included.
