Fig. 1: Adeno-associated virus (AAV) capsid structure.
From: Adeno-associated virus capsid assembly is divergent and stochastic
a The capsid is composed of 60 copies of a combination of VP1, VP2, and VP3. For the VPs we use the green, red, and gray color scheme, respectively, throughout the manuscript. The three VPs are encoded within the same cap ORF where the different VPs are produced via differential splicing and alternate start codons. All VPs share a common C-terminal VP3 sequence. b An AAV1 structure (PDB ID: 3NG9) radially colored from the capsid center (white to purple). The approximate icosahedral 2-, 3-, 5-fold axes along with the 2/5-fold wall are labeled. The icosahedral symmetry is retained by VP3, whereas the VP1 and VP2 extensions, and the variable stoichiometry result in a breakdown of this symmetry.
