Fig. 6: PRMT4, 5, 7, and hnRNPA1 arginine methylation were over-presented in multiple types of cancers. | Nature Communications

Fig. 6: PRMT4, 5, 7, and hnRNPA1 arginine methylation were over-presented in multiple types of cancers.

From: Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth

Fig. 6: PRMT4, 5, 7, and hnRNPA1 arginine methylation were over-presented in multiple types of cancers.

a–c Clinical samples of breast cancer (BRCA) (n = 10), colorectal cancer (CRC) (n = 10) and prostate cancer (PC) (n = 10) were subjected to RNA extraction and RT-qPCR analysis to examine the expression of PRMT4 (a), PRMT5 (b), and PRMT7 (c). Pearson correlation coefficient of the expression of PRMT4, PRMT5, and PRMT7 between normal and tumor samples is 0.60, −0.50, and −0.17 in BRCA, 0.12, 0.21, and −0.05 in CRC, and 0.48, 0.74, and 0.69 in PC, respectively. (*P < 0.05, **P < 0.01, ***P < 0.001 by paired Student t-test, two-tailed). d Arginine methylation sites in RGG domain of hnRNPA1 protein that could be detected and quantified in clinical samples of BRCA, CRC, and PC were shown. e–g Clinical samples of BRCA (e), CRC (f), and PC (g) were subjected to alternative splicing analysis as described in Fig. 4f. Source data are provided as a Source data file.

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