Fig. 3: Macrolide substrates and non-substrates in the active site of EreC.
From: Structural and functional insights into esterase-mediated macrolide resistance
Various macrolides modeled into the active site of EreC based on the conformation of erythromycin. The gray surface represents the active site of EreCClosed. Macrolides that are a substrate of EreC are colored in pink, spiramycin is colored in light green, and tulathromycin is colored in dark green. The catalytic water is represented as a red sphere. The arrows indicate the position of protein-macrolide steric clashes.
