Fig. 4: Cross-section of EreC with emphasis on the flexible loop.
From: Structural and functional insights into esterase-mediated macrolide resistance
a A cut-through section of EreCClosed with docked erythromycin shows the depth of the catalytic pocket and the protein-ligand interface. b View rotated 90° along the horizontal axis, with EreCClosed colored in light brown and EreCOpen colored in light blue. The active site loop is in two distinct conformation (arrows), which can cover the top of the active site and act as a lid.
