Table 1 Activity of erythromycin esterases against a panel of macrolides.

From: Structural and functional insights into esterase-mediated macrolide resistance

Ring size

Macrolide

EreC

EreB

EreD

14

Clarithromycin

S

S

S

Erythromycin

S

S

S

Oleandomycin

S

S

S

Pikromycin

S

S

S

Roxithromycin

S

S

S

Flurithromycin

S

S

S

Solithromycink

S

PS

NS

Telithromycink

NS

NS

NS

15

Azithromycin

S

S

S

Tulathromycin

NS

NS

NS

16

Spiramycin

NS

NS

NS

Josamycin

PS

NS

NS

Midecamycin

PS

NS

NS

  1. Substrates are classified as substrate (S) if >85% of macrolide was degraded, poor substrate (PS) for 30–85% degraded, and non-substrate (NS) for <30% degraded.
  2. k-ketolide antibiotic.
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