Table 1 Clinical characteristics of human donors of muscle cells.

From: VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics

 

Controls

Type 2 diabetes

p-value

n

14

14

 

Gender (male/female)

7/7

7/7

 

Age

54.2 ± 6.8

58.1 ± 6.6

0.14

Years of disease

 

4.8 ± 4.0

 

Height (m)

1.7 ± 0.1

1.7 ± 0.1

0.95

Weight (kg)

74.5 ± 14.2

80.3 ± 13.4

0.28

BMI (kg/m2)

24.7 ± 2.4

26.6 ± 3.1

0.07

Hip circumference (cm)

100.6 ± 4.7

100.6 ± 8.7

1.00

Waist circumference (cm)

85.9 ± 10.2

96.3 ± 8.7

0.01

Waist/hip ratio

0.9 ± 0.1

1.0 ± 0.1

0.01

Body lean mass/BW (%)

68.4 ± 8.7

64.4 ± 9.7

0.26

Body fat mass/BW (%)

27.4 ± 8.4

31.1 ± 9.1

0.27

Android fat mass/BW (%)

2.3 ± 0.7

3.2 ± 0.9

0.009

Gynoid fat mass/BW (%)

5.6 ± 2.2

5.3 ± 2.0

0.74

Android/Gynoid fat ratio

46.1 ± 18.0

65.3 ± 21.3

0.02

HbA1c (%)a

5.5 ± 0.2

6.7 ± 1.1

0.002

Glucose 0 h (mmol/L)

4.8 ± 0.6

9.1 ± 3.7

0.001

Glucose 2 h (mmol/L)b

5.2 ± 1.3

18.2 ± 6.6

4.7 × 10−6

Insulin 0 h (pmol/L)

32.1 ± 13.3

64.1 ± 41.9

0.02

Insulin 2 h (pmol/L)b

230.1 ± 155.3

371.5 ± 298.9

0.13

HOMA-IR (%)

1.0 ± 0.5

3.6 ± 2.3

0.001

HOMA-B (%)

74.4 ± 26.7

44.2 ± 36.6

0.02

C-peptide 0 h (pmol/L)

614.1 ± 144.4

817.6 ± 349.9

0.06

P-Cholesterol-total (mmol/L)

5.5 ± 1.0

4.5 ± 0.7

0.01

P-Cholesterol-HDL (mmol/L)

1.7 ± 0.5

1.3 ± 0.4

0.02

P-Cholesterol-LDL (mmol/L)

3.3 ± 0.9

2.5 ± 0.7

0.02

Systolic blood pressure (mmHg)

134.3 ± 12.0

140.8 ± 12.7

0.17

Diastolic blood pressure (mmHg)

85.6 ± 9.5

90.8 ± 6.3

0.10

Pulse (beats/min)

59.5 ± 12.4

68.6 ± 10.8

0.05

VO2 max (mL/min/kg)

32.6 ± 11.4

26.4 ± 7.6

0.10

  1. Data are presented as mean ± SD. Statistics were calculated using a two-tailed t-test.
  2. HbA1c glycated hemoglobin, BW body weight.
  3. aMeasured after 1 week without treatment.
  4. bMeasured after a 2 h oral glucose tolerance test.