Fig. 2: The predicted frequencies of cancer-specific KRAS alleles.
From: The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
a The predicted versus observed frequency of KRAS alleles for the common alleles of each cancer. Triangles indicate rejection of the null hypothesis that the observed and predicted frequencies are the same (χ-squared test, p values were adjusted using the Benjamini–Hochberg FDR correction method, hereon referred to as FDR-adjusted p values; FDR-adjusted p value < 0.05); circles indicate the failure to reject the null hypothesis (χ-squared test, FDR-adjusted p value \(\ge\) 0.05). Error bars indicate bootstrapped 95% confidence intervals of the predicted values. b The average probability of the indicated KRAS allele in tumors samples with the KRAS allele (closed circle), tumors samples with a different KRAS mutation (open circle), and tumor samples with WT KRAS (upside-down triangle). The errors bars indicate bootstrapped 95% confidence intervals of the mean. For each allele, differences in the probabilities between tumor samples with the allele and those with another allele, and between tumor samples with the allele and those with WT KRAS were tested via a Wilcoxon rank-sum test (FDR-adjusted p values < 0.05 are indicated). Source data are provided in the Source data file.
