Fig. 9: Compounds induce differential gene expression in the TG. | Nature Communications

Fig. 9: Compounds induce differential gene expression in the TG.

From: Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation

Fig. 9

a Clustered heat map depicting relationships across 12 genes, which exhibited significant differences (q < 0.01) under 16 stimulation conditions. The color bar indicates the z score scale. Egr1a and Egr1b are Ensemble transcript ENSMUST0000006479.5 and ENSMUST00000165033.1, respectively. b–i Box plots depicting the log estimated counts of gene expression in 16 stimulation conditions are shown for the indicated genes that exhibited significant differences (q < 0.01); n = 2 for saline, TO, AITC, and 2MT, and n = 4 for CNA and 4E2M; q = 0.00024 for Egr1b (b), q = 0.0012 for c-fos (c), q = 0.0024 for Btg2 (d), q = 0.0067 for Dusp1 (e), q = 0.0047 for Tbk1 (f), q = 0.0045 for AC149090.1 (g), q = 0.0058 for Tln2 (h), and q = 0.0083 for Col5a3 (i). All boxplots indicate median (center line), 25th and 75th percentiles (bounds of box), and minimum and maximum (whiskers); q value obtained by likelihood ratio test was corrected by Benjamin–Hochberg multiple test.

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