Fig. 1: Representative 8-oxopurine lesions.
From: DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
a Formation of 8-oxoguanine and related lesions from oxidation of guanine. Note that oxidative activation of oxoG in the presence of proteins can produce DNA-protein cross-links. b Formation of 8-oxoadenine and Fapy-A from oxidation of adenine. c Formation of the oxoA-imidazole adduct from the reaction of oxoA with imidazole in the presence of N-bromosuccinimide. [O] an oxidation event. NBS N-bromosuccinimide, Fapy-G/A formaminopyrimidine guanine/adenine.
