Fig. 6: The prevalence of T4SS among CD-associated E. coli. | Nature Communications

Fig. 6: The prevalence of T4SS among CD-associated E. coli.

From: High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

Fig. 6

a T4SS clusters of different CD-associated E. coli strains aligned to AIEC str. NRG857c. The gray shading represents the nucleotide similarity (BLASTn) between the aligned regions. traD homologs are shown in orange. The scale bar indicates genomic length in Kbp. b Abundance of different tra genes in the microbiome of CD patients and healthy donors presented as gene copy number per cell; n = 17 CD patients and 66 healthy individuals whose data were obtained from MetaQuery webserver. Boxes extend from 25th to 75th percentiles and whiskers show the minimum and maximum values. Lines at the middle of each box show the median. Groups were compared using two-tailed Mann–Whitney U test and Bonferroni–Dunn method to correct for multiple comparisons. Adjusted P values are 0.008733 for traD, 0.028551 for traG, 0.001586 for traI, and 0.000277 for traA.

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